Research areas

Cardiology

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"Heart wants what it wants" Indeed ?

Heart is the most important human organ in both physiological and literary terms. It is described as the source of the most important of feelings: love. Unhappy feelings can easily break them, but happy love can heal them immediately. Just a miracle!

And in the physiological sense? It is simply a muscle, stimulated to work by electrical stimulation, which pumps blood to the entire bloodstream. During the day, the heart beats about 100 thousand. times and pumps more than 7 thousand liters of blood. It weighs an average of 250 g and is the size of a clenched fist. From the point of view of our physiology, the heart is our faithful servant, a dedicated friend who unfortunately has little chance of regeneration.



"Closing the stable door after the horse has bolted!", unfortunately ...

Statistics are merciless: cardiovascular diseases account for 31% of all deaths in the world. About 17.2 million people die each year. It is expected to grow to more than 23.6 million in 2030. Among the cardiovascular diseases, the most fatal is coronary artery disease (CAD), which take the life of 500 thousand Americans, 1.8 million Europeans, including 75 thousand Poles each year.

The reasons of this are our main sins: inactive, stressful lifestyle, abnormal diet, smoking. The growing scale of the phenomenon creates the urgent need for effective and non-invasive diagnostics and monitoring of patients with coronary artery disease and at risk of heart attack. This would avoid many of these tragedies and make the gloomy message of the proverb "Closing the stable door after the horse has bolted" would not apply here.

 

"Cold eye, look in your heart"*, but how to do this?

We know how to look in the heart! Using a PET scanner (Positron Emission Tomography).PET offers a unique opportunity to quantify myocardial blood flow and coronary reserve in absolute terms that serve as a prognostic marker for adverse cardiac events. The use of radiotracers in cardiac diagnostics will allow for assessment of myocardial ischemia and indication for revascularization. Increasing the number of cardiac tests using a PET scanner will improve the diagnosis and thus the effectiveness of the treatment, patients with coronary artery disease and after the infarction. PET perfusion studies have a high diagnostic value, but the use of PET scanners in cardiac diagnostics is low. In the United States, myocardial diagnostics accounts for 50% of all diagnostic procedures for nuclear medicine, and for PET itself, less than 10%. In Europe this percentage is even smaller. This is due, inter alia, to the limited availability of effective radiotracers for the diagnosis of cardiovascular disease by PET.

That is why we have made every effort to develop an optimal radiotracer for the evaluation of myocardial perfusion in PET. Our Research and Development Center implements, directly funded by Synektik, and with the support of the European Union, cardiac probe projects. We have cooperation with Hadasit Medical Research Services & Development Ltd. in Jerusalem.

 

 

  CBR 12

 

 

 

 

„Opracowanie nowego kardioznacznika, znakowanego 18F, do oceny perfuzji mięśnia
sercowego i diagnostyki choroby wieńcowej w badaniu PET (Positron Emission Tomography)”


The project involves the development of a cardiac tracer labeled with 18F for the evaluation of myocardial perfusion and noninvasive coronary artery disease diagnostics during Positron Emission Tomography. It will enable early diagnosis of patients with coronary artery disease and after the infarction and will give the chance to implement appropriate treatment.


The project is co-financed under Measure 1.1 "R & D projects of enterprises" within the framework of
I Priority Axis: "Support for R & D by enterprises"
Operational Program Intelligent Development, 2014 - 2020.

 

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"Clinical performance validation of a novel biomarker for quantitative imaging of coronary artery disease"

 zdjecie UE